MethCP: Differentially Methylated Region Detection with Change Point Models (bioRxiv)

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1 MethCP: Differentially Methylated Region Detection with Change Point Models

Boying Gong, Elizabeth Purdom, MethCP: Differentially Methylated Region Detection with Change Point Models, 2018, bioRxiv.

https://doi.org/10.1101/265116 Permanent link to the paper]


1.1 Summary

A new approach (MethCP) for the identification of differentially methylated regions (DMRS) of the DNA based on whole genome sequencing data is supposed. The approach is develope for more complex design than two-group comparisons, e.g. for time course experiments. For the two-group setup, it is claimed that MethCP outperforms existing approaches.

1.2 Study outcomes

List the paper results concerning method comparison and benchmarking:

1.2.1 Outcome O1

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Outcome O1 is presented as Figure X in the original publication.

1.2.2 Outcome O2

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Outcome O2 is presented as Figure X in the original publication.

1.2.3 Outcome On

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Outcome On is presented as Figure X in the original publication.

1.2.4 Further outcomes

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1.3 Study design and evidence level

1.3.1 General aspects

You can describe general design aspects here. The study designs for describing specific outcomes are listed in the following subsections:

1.3.2 Design for Outcome O1

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  • Configuration parameters were chosen ...
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1.3.3 Design for Outcome O2

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1.3.4 Design for Outcome O

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1.4 Further comments and aspects

1.5 References

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